Protein Details: Chloride channel protein 2
Protein ID
ICDB_Pro_1696
Protein Name
Chloride channel protein 2
Gene Name
CLCN2
Organism
Cavia porcellus (Guinea pig)
Length
902 amino acids
AlphaFoldDB
AF-Q9WU45-F1-model_v4.pdb
Function
Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization; signal transduction and transepithelial transport (By similarity). Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization; activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase; the rate-limiting enzyme for aldosterone biosynthesis (By similarity).
Sequence
MAASAAAAGEGMEPRALQYEQTLMYGRYTQELGAFAKEEAARIRLGGPEPWKGPPSPRVPPELLEYGQSRCAPCCICSVRCHKFLVSRVGEDWIFLVLLGLLMALVSWAMDYAIAVCLQAQQWMSQGLNTNILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFVAKVIGLTCALGSGMPLGKEGPFVHIASMCASLLSKFLSLFGGIYENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFSATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTWVHQGLVEEQEPPSTSQAWNPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDGSTYRIVPGGYAVVGAAALAGAVTHTVSTAVIVFELTGQIAHILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPYVALNCTFRDLRLALHRTKGRMLALVESSESMILLGSIERSQVVTLLGAQLSAARRRQHIQERRKAQMSPPSDQDGLPSPESSVHFQVNTEDSAFIPARGETHKPLKPALKRGPSNASKAGETSTGSMESAGIALRSLFCGSPPPEATSDLEKPESCERRKLKRVRISLANDADLEGEMSPEEILEWEEQQLNEPVNFSDCKIDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAIEGSVTAQGVKVRPPLASFRDSATSSSDTETTEVHALWGPHSCHGLPRDGSPSDSDDKCQ
PDB Structures
Ligand Binding
Binding Site
Disease
Location
DOI ID
10.1152/ajpcell.2000.279.4.c1198